The Mercedes-Benz R-Class is the brand's crossover vehicle, created for buyers seeking the driving dynamics of a luxury sedan with the space and functionality of a sport utility. It can accommodate up to seven passengers in comfort, with three rows of seating, four conventional doors and a top-hinged rear liftgate for easy access to the cargo area.

The R-Class is offered in two versions: the R350 and the new R350 BlueTEC. The R350 is powered by a 268-hp 3.5-liter V6 gasoline engine, while the R350 BlueTEC gets a 210-hp 3.0-liter turbocharged direct diesel injection V6, featuring BlueTEC clean diesel technology for enhanced fuel efficiency. Both models are equipped with a seven-speed automatic transmission, including TouchShift manual shift control and steering wheel paddles, as well as full-time 4MATIC all-wheel drive. Every R-Class model is outfitted with a power sunroof, power rear quarter windows, automatic climate control and a COMAND system with 6-disc CD, DVD audio/video player and Bluetooth wireless connectivity. Standard safety features include stability and traction control systems, anti-lock disc brakes with brake assist, first- and second-row side-impact airbags, overhead curtain airbags for all three rows, active anti-whiplash front head restraints and the Mercedes PRE-SAFE predictive occupant protection.

For 2010, the Mercedes-Benz R-Class gets new standard 19-inch alloy wheels (AMG-design on the R350) and a tire-specific pressure monitor. Additionally, the R350 BlueTEC replaces the previous model year's R320 BlueTEC.